Rusty Lansford, PhD
Senior Scientist in Biology and Instructor in Bioengineering
California Institute of Technology
Beckman Institute 139-74
Pasadena, CA 91125 USA
Off: (626) 395-2004
Lab: (626) 395-2863
E: rusty@gg.caltech.edu


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PUBLICATIONS (Under construction)

Peer-reviewed Publications
Canaria, C.C., Maloney, J.R., Yu, C.J., Smith, J.O., Roukes, M., Fraser, S.E., and Lansford, R. (2005, Mansucript submitted) Formation and removal of biotinylated alkanethiolate self-assembled monolayerson gold from aqueous solutions.
Teddy, J., Lansford, R., and Kulesa, P. (2005, In press) Four color imaging using fluorescent proteins in living chick embryos. Biotechniques 39,.
Canaria, C.C., Yu, C.J., Smith, J.O., and Lansford, R. (2005) A novel synthesis for biotin triethyleneglycol dodecylthiol. Tetrahedron Letters 46, 4813-4816.
LaRue, A.C., Lansford, R., and Drake, C.J. (2003) Blood island-derived stem cells contribute to intraembryonic vasculogenesis. Dev Bio. 262(1),162-72. [Link to the Paper]
Carleton, A., Petreanu, L.T., Lansford, R., Alvarez-Buylla, A., and Lledo, P.M. (2003) Becoming a new neuron in the adult olfactory bulb. Nat Neurosci. 6, 507-18.
Lansford, R., Bearman, G., and Fraser, S.E. (2001) “Resolution of multiple GFP color variants and dyes using two-photon microscopy and imaging spectroscopy.” J Biomed Optics 6, 311-18.
Thakur, A., Lansford, R., Thakur, V., Narone, J.N., Atkinson, J.B., Buchmiller-Crair, T., and Fraser, S.E. (2001) “Gene transfer to the embryo: strategies for the delivery and expression of proteins at 48 to 56 hours post-fertilization.” J Pediatr Surg 36, 1304-7. [Link to the Paper]
Okada, A., Lansford, R., Weimann, J.M., Fraser, S.E., and McConnell, S.K. (1999) "Imaging cells in the Developing Nervous System with retrovirus Expressing Modified Green Fluorescent Protein." Exp. Neurol. 156, 394-406.
Cunningham, K., Ackerly, H., Claflin, L., Collins, J., Wu, P., Ford, C., Lansford, R., Alt, F., and Dunnick, W.A. (1998) “Germline transcription and recombination of a murine VDJ-mu delta gamma1transgene.” Int. Immunol. 10, 1027-1037.
Lansford, R., Manis, J., Sonada, E., Rajewsky, K., and Alt, F.W. (1998) “B18l complementation of mutant mice: Model system for characterizing factors essential for immunoglobulin class switch recombination.” Int. Immunol. 10, 325-332.
Manis, J.P., Gu, Y., Lansford, R., Ferrini, R., Davidson, L., Rajewsky, K., Alt, F.W. (1998) “Ku70 is required for late B cell development and immunoglobulin heavy chain class switching,” J. Exp. Med. 187, 1-9.
Krull, C. E.*, Lansford, R.*, Gale, N.W., Collazo, A., Marcelle, C.,Yancopoulos, G.D., Fraser, S.E., and Bronner-Fraser, M. (1997) Interactions of eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration Curr Biol 7, 571-580 (*Contributed equally to the paper).
Cogne, M.*, Lansford, R.*, Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H.L., and Alt, F.W. (1994) "A master class switch control region at the 3'end of the IgH locus," Cell, 77, 737-747 (*Contributed equally to the paper).
Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T.K., Mendelson, M., Rolink, A., Melchers, F., and Alt, F.W. (1994) "Influence of immunoglobulin heavy and light chain expression on B cell differentiation, Genes Dev, 8: 1043-1057.
Bottaro, A., Lansford, R., Xu, L., Zhang, J., Rothman, P., and Alt, F.W. (1994) "S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process," EMBO J, 13, 665-674.
Chen, J., Lansford, R., Stewart, V., Young, F., and Alt, F. (1993) "RAG-2 deficient blastocyst complementation: An assay of gene function in lymphocyte development," PNAS USA 90: 4528-4532.
Lansford, R.D., McFadden, H., Sui, S.T., Cox, J.S., Cann, G., and Koshland, M.E. (1992) "A promoter element that exerts positive and negative control of the interleukin 2-responsive J-chain gene," PNAS USA 89: 5966-5970.
Yancopoulos, G. Oltz, E. Rathbun, G. Berman, J. Smith, R. Lansford, R., Rothman, P., Okada, A. Lee, G. Morrow, M. Kaplan, K. Prockop, S. and Alt, F. (1990) "Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development," PNAS USA 87: 5759-5763.

Invited Reviews
Lansford, R. (2004) “Viral vectors for introduction of GFP,” in Live Cell Imaging: A Laboratory Manual,. Ed. by R. Goldman and D. Spector, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
Dickinson, M.E., Bearman, G., Tille, S., Lansford, R. and Fraser, S.E. (2001) “Multi-spectral Imaging and Linear Unmixing Adds a Whole New Dimension to Laser Scanning Fluorescence Microscopy” Biotechniques 31, 1272-1279.
Lansford, R., Krull, C. E., Bronner-Fraser, M., and Fraser, S.E. (1999) “Role of Eph receptors in patterning trunk neural crest migration,” in Frontiers in Neural Development, Springer-Verlag, Tokyo.
Lansford, R., Okada, A. Rathbun, G., Chen, J., Oltz, G., Alt, F.W. (1996) "Mechanism and control of immunoglobulin gene rearrangement" in Molecular Immunology , Molecular Biology series, ed. B. D. Hames, IRL Press, p 1-100.

PATENTS
Bearman, G.H., Fraser, S.E., and Lansford, R. (2000) System and method for monitoring cellular activity. Patent issued (US #6,403,332).
Work in laser microscopy and imaging spectrometry led to the development of a multispectral imager that allows the emission spectrum to be acquired from a single scan of the specimen. A multispectral detector based on our invention has been built and is being sold by Zeiss as the LSM 510 META.