Rusty Lansford, PhD
Senior Scientist in Biology and Instructor in Bioengineering
California Institute of Technology
Beckman Institute 139-74
Pasadena, CA 91125 USA
Off: (626) 395-2004
Lab: (626) 395-2863
E: rusty@caltech.edu
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EDUCATION
1996 Columbia University, College of Physicians and Surgeons, New York, NY. Ph.D. in Immunology
1990 Columbia University, College of Physicians and Surgeons, New York, NY. M.S. in Immunology
1989 Columbia University, College of Physicians and Surgeons, New York, NY. M.A. in Immunology
1986 University of California, Berkeley, Berkeley, CA. A.B. in Microbiology & Immunology
RESEARCH INTERESTS
Dynamic analysis of forebrain and midbrain development, Interplay between genetics and hemodynamics in heart formation, DNA recombination in ES cells, Transgenic Avians, Bio-detection using Nanodevices, Advanced Optical Microscopy, Global Health & Poverty
APPOINTMENTS
Senior Scientist and Instructor, Division of Biology and Bioengineering, California Institute of Technology (2002-present).
Affiliated Professor in Neurobiology and Cell Biology, Montana State University (11/01-present).
Senior Research Fellow, Division of Biology and Biological Imaging Center, California Institute of Technology (1999-2002).
Postdoctoral fellow in Dr. Scott Fraser's lab, Division of Biology and Biological Imaging Center, California Institute of Technology (1996-1999).
Graduate student in Dr. Fred Alt's lab in the Department of Microbiology and Immunology at Columbia University (1989-1991) and in the Department of Genetics at Harvard University (1991-1995).
Undergraduate honor's thesis and research assistant in Dr. Marian Koshland's lab in the Department of Immunology at University of California, Berkeley (1985-1989).
HONORS AND AWARDS
2003 NASA Space Act Award for Two-photon Microscope Imaging Spectrometer for Multiple Fluorescent Probes (along with Greg Bearman and Scott Fraser).
2002 R&D 100 Award winner for development of META multispectral imager (along with Greg Bearman, Scott Fraser, and Carl Zeiss Jena GmbH).
Visiting Scholar of Thermal Biology at Montana State University, Bozeman, MT (2001)
SELECTED PUBLICATIONS
Ruffins, S.W., Martin, M., Fraser, S.E., Jacobs, R.E., and Lansford, R. (2006, manuscript submitted) Three-Dimensional Atlas of Quail Development Using High-Resolution MRI. TheScientificWorld.
Cui, C., Lansford, R., Filla, M.B., Little, C.D., Cheuvront, T.J., and Rongish, B.J. (2006, in press) Electroporation and GFP labeling of gastrulating quail embryos. Dev Dyn
Canaria, C.C., Maloney, J.R., Yu, C.J., Smith, J.O., Fraser, S.E. and Lansford, R. (2006) Formation and removal of biotinylated alkanethiolate self-assembled monolayers on gold from aqueous solutions. Lab Chip. 6, 289-295.
Canaria, C.C., Smith, J.O., Yu, C.J., and Lansford, R. (2005) A novel synthesis for biotin-triethyleneglycol dodecylthiol, Tetrahedron Letters. 46, 4813-4816.
Teddy,J. Lansford, R. and Kulesa, P. (2005) Four color imaging using fluorescent proteins in living chick embryos, Biotechniques. 39, 703-710.
Carleton, A., Petreanu, L.T., Lansford, R., Alvarez-Buylla, A., and Lledo, P.M. (2003) Becoming a new neuron in the adult olfactory bulb. Nat Neurosci. 6, 507-18.
Lansford, R., Bearman, G., and Fraser, S.E. (2001) “Resolution of multiple GFP color variants and dyes using two-photon microscopy and imaging spectroscopy.” J Biomed Optics 6, 311-18.
Okada, A., Lansford, R., Weimann, J.M., Fraser, S.E., and McConnell, S.K. (1999) "Imaging cells in the Developing Nervous System with retrovirus Expressing Modified Green Fluorescent Protein." Exp. Neurol. 156, 394-406.
Lansford, R., Manis, J., Sonada, E., Rajewsky, K., and Alt, F.W. (1998) “B18l complementation of mutant mice: Model system for characterizing factors essential for immunoglobulin class switch recombination.” Int. Immunol. 10, 325-332.
Krull, C. E.*, Lansford, R.*, Gale, N.W., Collazo, A., Marcelle, C.,Yancopoulos, G.D., Fraser, S.E., and Bronner-Fraser, M. (1997) Interactions of eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration Curr Biol 7, 571-580 (*Contributed equally to the paper).
Cogne, M.*, Lansford, R.*, Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H.L., and Alt, F.W. (1994) "A master class switch control region at the 3'end of the IgH locus," Cell, 77, 737-747 (*Contributed equally to the paper).
Bottaro, A., Lansford, R., Xu, L., Zhang, J., Rothman, P., and Alt, F.W. (1994) "S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process," EMBO J, 13, 665-674.
Chen, J., Lansford, R., Stewart, V., Young, F., and Alt, F. (1993) "RAG-2 deficient blastocyst complementation: An assay of gene function in lymphocyte development," PNAS USA 90: 4528-4532.
Invited Reviews
Lansford, R. (2006, manuscript in preparation) “Generation of transgenic avians,” in Ed. by M. Bronner-Fraser.
Lansford, R. (2004) “Viral vectors for introduction of GFP,” in Live Cell Imaging: A Laboratory Manual,. Ed. by R. Goldman and D. Spector, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
Lansford, R., Krull, C. E., Bronner-Fraser, M., and Fraser, S.E. (1999) “Role of Eph receptors in patterning trunk neural crest migration,” in Frontiers in Neural Development, Springer-Verlag, Tokyo.
Lansford, R., Okada, A. Rathbun, G., Chen, J., Oltz, G., Alt, F.W. (1996) "Mechanism and control of immunoglobulin gene rearrangement" in Molecular Immunology , Molecular Biology series, ed. B. D. Hames, IRL Press, p 1-100.
PATENTS
Bearman, G.H., Fraser, S.E., and Lansford, R. (2000) System and method for monitoring cellular activity. Patent issued (US #6,403,332).
Work in laser microscopy and imaging spectrometry led to the development of a multispectral imager that allows the emission spectrum to be acquired from a single scan of the specimen. A multispectral detector based on our invention has been built and is being sold by Zeiss as the LSM 510 META.
Canaria, C., Lansford, R. and Fraser, S.E. Aqueous Techniques for the Formation and Desorption of Self-Assembled Monolayers on Gold Electrodes: Faster Monolayer Formation and Recycling Techniques for Micro/Nano-Electrode. Patent pending (Serial # 60/702,689).
Lansford, R. Efficient BAC Transfection of Stem Cells. Patent pending (Serial # CIT-4612-P).
PROFESSIONAL AND ADVISORY POSITIONS
Member of Caltech Biosafety Committee (Provost Appointed)
Review committee member of Caltech Women’s Center (Provost Appointed)
Review committee member of Caltech Racial Equality
Scientific Consultant-Aliva Pharmaceuticals, Pasadena, CA.
Founder-Ovogenics, Claremont, CA.
TEACHING
Bioengineering 201 at Caltech (2003-present)
Immunology at UCLA (2005)
“Advanced Techniques in Molecular Neuroscience” course at Cold Spring Harbor Laboratory (2005-present)
Developed and organized high school teaching platform with Teachers Institute and museum exhibits with San Francisco Exploratorium and California Science Center using the Quail Developmental Atlas as a biology, math, and physics educational tool.
JOURNAL REFEREE
1996-present
Ad hoc reviewer Developmental Biology
Ad hoc reviewer Development
Ad hoc reviewer Science
Ad hoc reviewer Nature
Ad hoc reviewer Developmental Dynamics
Ad hoc reviewer PLoS
Ad hoc reviewer Immunity
Ad hoc reviewer Cell
Ad hoc reviewer Neuron
Ad hoc reviewer Lab on a Chip